SLU-PP-332

SLU-PP-332 is a small molecule that acts as a potent, non-selective agonist of oestrogen-related receptors (ERRs), particularly ERRα. Developed at Saint Louis University School of Medicine, it has garnered attention for its potential applications in metabolic health, exercise mimetics, and bodybuilding.

These effects collectively improve cellular energy production, fat oxidation, and overall metabolic efficiency. 

Sublingual: Better absorption/Exercise mimetic effect/Fat loss & Metabolic health

60 x 1000mcg tablets

Benefits seen in studies-

1. Exercise Mimetic Effects

SLU-PP-332 mimics the physiological effects of exercise, providing benefits such as:
Increased mitochondrial density in skeletal muscle.
Enhanced expression of GLUT4 glucose transporters in muscle tissue.
Improved muscular endurance and running capacity.
Reprogramming of muscle fibre type composition toward more oxidative phenotypes.
Increased vascular density in skeletal muscle.
Enhanced cardiac efficiency through improved mitochondrial function.
In another paper published in March, the researchers reported that they had observed that the compound allowed normal-weight mice to run for 70% longer and 45% further than mice not receiving SLU-PP-332.

2. Fat Loss and Metabolic Health

Studies in animal models have shown that SLU-PP-332 improves insulin sensitivity and reduces adiposity, while anecdotal evidence shows that SLU-PP-332 is exceptional as a fat loss agent. When administered to diet-induced obese mice, SLU-PP-332 produced:
18-24% reduction in body weight.
30-35% decrease in white adipose tissue mass.
40% improvement in glucose tolerance.
25-30% decrease in fasting insulin levels.
Significant reduction in hepatic steatosis and inflammation.

3. Mitochondrial Health and Aging

SLU-PP-332 has been studied for its role in reversing mitochondrial dysfunction and inflammation in aging tissues. In aged rodent models, SLU-PP-332 demonstrated:
Restoration of mitochondrial respiration rates in kidney and liver tissues.
Reduction in age-associated inflammation markers (IL-6, TNF-α).
Decreased oxidative damage to mitochondrial DNA.
Improved autophagy and mitophagy.
Attenuation of fibrotic tissue changes in kidneys and heart.

4. Muscle Mass Maintenance:

It may help preserve muscle mass
Improved insulin sensitivity.
Improved Muscle mitochondrial function.
Improved endurance.