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  • Looking for a potent GH release that doesn’t involve needles and frustrating timing schedules? Ibutamoren (mk-677) may just fit the bill…

SARM MK-677 Ibutamoren

£44.95 (inc VAT) £37.46 (exc VAT)
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0.09 KGS
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Product Description

Ibutamoren: Oral Growth Hormone Release

Looking for a potent GH release that doesn’t involve needles and frustrating timing schedules? Ibutamoren (mk-677) may just fit the bill…

I have always been a huge fan of Ipamorelin and CJC1295 (modified GRF 1-29) when it comes to increasing Growth Hormone levels. But those two peptides require injections, and to really see benefits, you have to inject it multiple times a day, and plan your meals out accordingly (you want to be fairly fasted before using these, and then wait for at least 30 minutes before eating afterwards). So for those of you who don’t want to jack with all that, and want a continuous, 24 hour increase in GH, IGF-1 and IGF-BP3, then Ibutamoren, an orally active GH secretagogue may be just the ticket.


The benefits of Growth Hormone on metabolism and lean body mass are undeniable. I also go to great lengths pointing out that I don’t think GH is much of a muscle builder per se, and that its ultimate benefit comes down to controlling, or rather off-setting, the detrimental effects of insulin on body composition, when it comes to excessive fat gain. Insulin and IGF-1 are amazing at increasing protein synthesis, no doubt, but the real benefits after extended trials of anything that increases GH levels seem to come more in the way of increased leanness, and decreased fat storage.

For many, the use of HGH is not only too costly, but is not a good route to go if overall health and longevity is of utmost importance. HGH, injected exogenously, can create a really awesome environment for body transformation, but with that comes the price of shutting down the HPA production of natural pulses, which interferes with an overall healthier body, for lack of a more scientific term. HGH is great at doing what it does, but leaving it “on” for 8 hours post injection, can lead to insulin resistance and water retention imbalances that ultimately take their toll on the body, especially if someone is using large doses. GH is not supposed to be a 24 hour ON button. It is supposed to peak and drop, along with other hormones, to create the perfect environment for long-term health and anti-aging benefits.

Enter the injectable GH releasers such as Ipamorelin and GRF. These are very, very good at getting the job done when it comes to increasing the body’s own production of Growth Hormone. The biggest problem, though, is that to really take advantage of the benefits, and to fully utilize the peaks, a person would have to inject multiple times a day, and plan out their diet accordingly (too much food in the gut will dampen the release and peak of the GH).

But with an orally active version like Ibutamoren, a single dose can increase benefits throughout the entire day, without the need for carrying around needles, watching your diet before and after injections, and all that crap that goes with playing with GH releasers.

And the results from the studies I’ve seen, show promising results.
 

Here is a graph showing the benefits continued to come over a year using Ibutamoren. In many instances, these GH releasers would fizzle out after a month, so seeing a consitent benefit over such a long period is a huge thing!

mk677.jpg
Effects of a 7-day treatment with a novel, orally active, growth hormone (GH) secretagogue, MK-677, on 24-hour GH profiles, insulin-like growth factor I, and adrenocortical function in normal young men.

To assess the effects of prolonged administration of a novel analog of GH-releasing peptide (MK-677), nine healthy young men participated in a randomized, double blind, three-period cross-over comparison of orally administered placebo and 5- and 25-mg doses of MK-677. Each period involved bedtime administration of the drug for 7 consecutive days. At the end of each period, plasma levels of insulin-like growth factor I (IGF-I) and IGF-binding protein-3 (IGFBP-3) were measured at 0745 h, and 24-h profiles of plasma GH and cortisol were obtained at 15-min intervals together with the 24-h urinary excretion of free cortisol. Profiles of plasma free cortisol were calculated at hourly intervals. The amounts of GH secreted were similar in all three conditions, but GH pulse frequency was increased with both dosages of the drug, primarily because of an increase in the number of low amplitude pulses. Plasma IGF-I levels were increased in a dose-dependent manner, whereas IGFBP-3 levels were increased only with the highest dosage. There was a positive relationship between GH pulse frequency and IGF-I increase. Except for an advance in the nocturnal nadir and in the morning elevation, MK-677 had no effect on cortisol profiles. In particular, 24-h mean levels of plasma total and free cortisol and urinary excretion of free cortisol were similar under all conditions. The present data suggest that the use of MK-677 for the treatment of relative somatotropic deficiency, particularly in older adults compromised by such deficiency, deserves further investigation.

 

And a quick note about the cortisol effects… A lot of these peptides increase Cortisol, which is definitely not wanted during the peak of GH release, if physical transformation is a goal. Many of these also increase Prolactin, which can cause a lot of other side-effects.  So an orally active GH releaser that doesn’t increase Cortisol is definitely going to be a game changer.

Two-Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK-677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure

We conclude that 2-month treatment with MK-677 in healthy obese males caused a sustained increase in serum levels of GH, IGF-I, and IGF-binding protein-3. The effects on cortisol secretion were transient. Changes in body composition and energy expenditure were of an anabolic nature, with a sustained increase in fat-free mass and a transient increase in basal metabolic rate. Further studies are needed to evaluate whether a higher dose of MK-677 or a more prolonged treatment period can promote a reduction in body fat.

 

Another quick point. IGF-BP3 increases are a good thing. In some instances, we see a binding protein and think of SHBG, Sex Hormone Binding Globulin, which arguably makes Testosterone less effective. In this instance, however, the binding protien IGF-BP3 is needed to carry the IGF-1 into the cell and activate the receptor. So anything that increases IGF-1 AND also increases BP3 is a definite benefit.

 

Supplement Facts

90 Capsules per container

Amount per Serving                                

MK-677 (Ibutamoren)                                10mg

(R)-1'-(2-methylalanyl-O-benzyl-D-seryl)-1(methylsulfonyl)-1,2-dihydrospiro(indote-3,4'piperidine)

 

This product is by no means intended to diagnose, treat or cure any medical condition and are not to be considered a medicine.

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Product Reviews

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Showing reviews 1-10 of 31 | Next

  1. good product and very good service.

    Posted by YM on 14th Dec 2018

    I was very impressed with service.
    Good product, caring staff


  2. Perfect!

    Posted by Sam on 30th Nov 2018

    The product is good. Noticed changes straight away. I've only been on it for 2 weeks and I'm literally growing after every training session. I'm doing only 10mg before bed. The pumps on this are awesome. It is good to have some inositol and choline supplement, just to keep the liver healthy. I haven't seen noticeable increase in strength for now, but we'll see how it goes. Had a little problem with cramps the first couple of days, but I have adjusted my potassium and magnesium intake and everything is back to normal now. Also it's good to monitor your sodium intake while cycling this, because of the water retention, but depending on your body fat % it can actually be a benefit, because the muscles look fuller. Overall very good product.


  3. the best MK 667 in capsules on the market

    Posted by Marcin on 20th Oct 2018

    I've tried many different brand of MK 677 (caps/tabs) and without a doubt the DNA Anabolics MK 677 is second to none on the market! On only 20mg e/d you can fell the benefits after a couple of days. improved the sleep pattern, lean body mass and increased appetite(for someone this can be side effect). It goes better when the dose is increased to 30-40mg, side effect are mild and not harmful (for me) and these are such as lethargy and numb limbs sometimes. The best thing is that even when I was off from gym for 6 weeks and still used 10-20mg e/d, my muscles/strength were not dropped significantly and was much easier to back on track when I've started training again.
    Thanks JW SUPPLEMENTS to have this product for sale!!


  4. Great Sarm

    Posted by Andreas Alm on 19th Jun 2018

    Great product so far! Before I start my review, let me tell you something. I were a skinny guy who spent alot of time at the gym and tried to eat as much as possible (high calorie diet). But I struggled with "hunger feeling". No matter how much I pushed myself to eat every third hour, I still didn't get the feeling of being hungry. So I heard about this product. What you should know is that this product rapidly increases your hunger. That's why I mainly started to try these. Let's get back to the review shall we?

    Started my bulk cycle off with only using MK677 for 2 weeks. Taking 20MG/day (2 capsules before bedtime).
    During the first week I didn't see any physical results in lean body mass (didn't expect to do so either this early). However my hunger had increased alot and I ate about 5-7 meals per day with a hight protein and calorie intake. On the second week I started to notice the difference. My body shape had started to change and my muscle growth had increased and also my endurance.
    Third week, I stacked these with Tr3st from OL and here is where the magic happend.

    Did a 4 week cycle with Tr3st toghether with MK677 (had MK677 for 6 weeks).
    Gained a total of 15KG. Have been on my PCT (You don't need a pct if you're running mk677 only, why im on pct is due to the Tr3st) for two weeks now, using "Perfect PCT" and haven't felt anything negative. My endurance is great, stamina is great and my libido is great. The best part, haven't lost a single "KG" during my PCT.

    To this I also have to add that I hard a strict food schedule of a high protien and calorie intake. Went to the gym 6 times a week with a professional workout schedule.

    All this being said, I strongly recommend this product and as mentioned above, if u looking for serious mass gain these are perfect to stack with.


  5. Great stuff.

    Posted by Del Bains on 28th Mar 2018

    Great stuff, I'm sure it is working. I feel the difference. I'm sure it's not a placebo effect. Will buy another.


  6. Slow and steady

    Posted by Nox on 13th Mar 2018

    This is the second bottle I have run, so have been using mk-677 at a low dose for a month and a half.
    Despite my diet not being the best it could and my training being a little off the boil I've kept some decent muscle and strength. I'd definitely recommend mk677, but I wouldn't expect big results like a course of test. After a month I haven't noticed any adverse side affects, a little bloating from water retention early on, but that soon passed.


  7. mk667 update

    Posted by Fabz on 10th Mar 2018

    good product would highly rate it a good source to buy from.good pumps in the gym great restful sleep woke feeling full of energy for the day.I also had really weird dreams while taking mk667 an strange tingle sensations in fingers an hands.I would say this product is good as a great well being supplement so far as only been consuming for 4weeks so far so good!!


  8. Sarm MK-677

    Posted by Unknown on 5th Mar 2018

    Been on mk-677 for 2 weeks. 20mg a day. 10mg in the morning and 10mg before bed. No result yet only been 2 weeks. No change in the gym no added strength.
    Going to give it 2 months. Hope these mk-677 are legit.

    JW response:
    MK-677 is best taken if both capsules are taken at night.


  9. Used several bottles

    Posted by Allan VanHofwegen on 31st Jan 2018

    My wife and I both take one capsule each evening. Good pumps in the gym and vivid dreams during sleep. Slight increased water retention. I like this product. We are both in our late forties. Good alternative to growth hormone. My wife did not like the water retention she experienced from growth hormone.


  10. 100% real

    Posted by Unknown on 11th Jan 2018

    Legit mk677. Good pumps, sleep and recovery. Super powerfull. Took it before bed. I think 20mg is sweet spot for me . Felt lethargic and sleepy all day first which subsided after couple weeks.


Showing reviews 1-10 of 31 | Next

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