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  • OR1GIN – The King of Natural Anabolics


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The desire to be bigger and stronger is an objective a large subset of the bodybuilding

community possess. To realize that goal by natural means has eluded those who covet the

extreme size. Sure, there are several respectable natural anabolic supplements currently

available such as Olympus Labs -epicatechin product, EP1C UNLEASHED. But lets be REAL,

they’re not in the same realm as a PH. That unfortunate reality makes the

temptation to use a PH too appealing for many to resist. For those that are not willing to accept

the risks that several PH products present, they be may destined to remain ”small”?

Unless the DemiGods at Olympus Labs can solve this conundrum and help you get HUGE!.

We went back to the fundamentals to create the ultimate catalyst for natural growth. Olympus

Labs is proud to announce a TR1UMPH in the natural anabolic category with the inception of

OR1GIN – The King of Natural Anabolics. It is the missing link in your quest to transform from a

mere mortal into a DemiGod.

It is a revolutionary supplement that will not have an impact on the Hypothalamic Pituitary

Testicular Axis (HPTA), glands in the human body that affect the production of testosterone.

Yet it is so advanced it will stimulate muscle growth never realized before from a natural product

and will undoubtedly change your approach to supplementation. Olympus Labs has created the

OR1GIN of muscle building to re-define your physique – naturally. There is now a viable

alternative for those who want to boost muscle anabolism without the use of prohormones.

OR1GIN is also a perfect addition to a pro-hormone cycle or to use as part of a post-cycle

therapy (PCT) to maintain your gains.

So how does OR1GIN work exactly? Well, I am sure you are familiar with the popular cliche in

the bodybuilding community; “you need to eat to grow”. That is a very simplistic perspective

and often misinterpreted by those who follow bro-science. Although it may be easy to

significantly increase caloric intake with foods high in fat and sugar, It is not as easy to do so

while adhering to a healthy diet. To avoid eating when you are not hungry otherwise known as

“force feeding“, an increase in appetite would be ideal. In addition, you want to ensure your

body utilizes those extra calories in the most efficient manner, mainly in the form of skeletal

muscle. Guess what? OR1GIN adeptly performs those two functions via ghrelin secretion and

ribosome biogenesis. In order to understand the potential of OR1GIN, let’s review these two

mechanism of actions.


ORIG1N Features:

Enhanced Ribosome Biogenesis


Increased Ghrelin Release & Myogenin Synthesis


Increased IGF-1 Signaling


Accelerated Recovery & Tissue Healing


Increased Appetite & Improved Digestion/Nutrient Uptake


Ghrelin Secretion

Ghrelin is an endogenous ligand, GHS-R1a, of the growth hormone secretagogue receptor that

can cause a significant increase in appetite. In fact, Ghrelin is the only hormone that exhibits

this appetite enhancement, or orexigenic effect, following peripheral administration. In addition,

ghrelin exhibits a variety of actions, including stimulation of growth hormone secretion, gastric

motility, and gastric acid secretion, as well as induction of a positive energy balance. This

hormone, predominantly expressed and secreted by the stomach, has a dual action on GH

secretion and food intake. It is believed to be the link connecting somatic growth and body

composition with energy metabolism.


Ribosome Biogenesis

The ribosome is a nucleoprotein particle responsible for one of the key processes in every cell,

the decoding of messenger ribonucleic acid (mRNA) into protein. mRNA is a set of RNA

molecules that translate genetic information from DNA to the ribosome. Formation of the

ribosomal particle, also referred to as ribosome biogenesis, involves a complex series of

processes (synthesis, processing and modification) of both ribosome ribonucleic acid (rRNA)

and ribosomal proteins, and assembly of the components. Ribosomes play a pivotal role in the

molecular life of every cell and rRNA is a critical component of protein synthesis. The

biogenesis of ribosomes is a tightly regulated activity and it is inextricably linked to other

fundamental cellular processes, including growth, or muscle hypertrophy, and cell division as

the studies below demonstrate.

Forty-two older adults underwent a 4 week resistance exercise training (RT)

program to validate the hypothesis that the extent of hypertrophy is at

least partly regulated by the amount of RT-induced ribosome biogenesis.

The study aimed to induce hypertrophy with knee extensors (e.g. 2 sets of

squat, leg press, and knee extension, 10-12RM, 3d/wk), and vastus lateralis

muscle biopsies were performed pre- and post-RT. Post hoc K-means cluster

analysis revealed distinct differences in Type II myofiber hypertrophy

among subjects. The percent change in Type II myofiber size in non-

responders (Non; n=17) was -7%, moderate responders (Mod; n=19) +22%, and

extreme responders (Xtr; n=6) +83%. Total muscle RNA increased only in Mod

(+9%, p<0.08) and Xtr (+26%, p<0.01), and only Xtr increased rRNA content

(+40%, p<0.05) and myonuclei/type II fiber (+32%, p<0.01). Additionally,

Mod and Xtr had a greater increase in c-Myc protein levels when compared to

Non (e.g. ≈+350% and ≈+250% vs. +≈50%, respectively; p<0.05). In vitro

studies showed that growth factor-induced human myotube hypertrophy is

abolished when rRNA synthesis is knocked down using the Pol I-specific

inhibitor, CX-5461. Overall, these data indicate ribosome biogenesis as a

key process regulating the extent of RT-induced myofiber hypertrophy in

older adults.


An animal study was performed to analyze the impact of increases in the protein translation rate

from external loads on muscle hypertrophy. Male rats were assigned to four groups in which the

plantaris muscle was unilaterally subjected to weak (WK), moderate (MO), middle (MI), and

strong (ST) overloading by four types of synergist ablation. Fourteen days after surgery, the

weight of the plantaris muscle per body weight increased by 8%, 22%, 32% and 45%, in the

WK, MO, MI and ST groups, respectively. Five days after surgery, 18+28S rRNA content (an

indicator of translational capacity) increased with increasing overload, with increases of 1.8-fold

(MO), 2.2-fold (MI), and 2.5-fold (ST), respectively, relative to non-overloaded muscle (NL) in

the WK group. rRNA content showed a strong correlation with relative muscle weight measured

14 days after surgery (r = 0.98). The phosphorylated form of p70S6K (a positive regulator of

translational efficiency) showed a marked increase in the MO group, but no further increase was

observed with further increase in overload (increases of 22.6-fold (MO), 17.4-fold (MI), and

18.2-fold (ST), respectively, relative to NL in the WK group). These findings indicate that

increases in ribosome biogenesis at the early phase of overloading are strongly dependent on

the amount of overloading, and may play an important role in increasing the translational

capacity for further gain of muscular size.

A clinical study with mice sought to examine the hypothesis that a change in the expression of

protein-encoding genes in response to a hypertrophic stimulus contributes to the blunted

hypertrophy observed with aging. To test this theory, gene expression of plantaris muscle from

5 month and 25 month old mice were subjected to synergist ablation to induce hypertrophy over

the course of two weeks. A similar pattern of expression between the two groups was found.

Despite ribosome protein gene expression being higher in the aged group, ribosome biogenesis

was significantly blunted in the skeletal muscle of aged mice compared with mice young in

response to the hypertrophic stimulus (50% vs. 2.5-fold, respectively). The failure to upregulate

pre-47S ribosomal RNA (rRNA) expression in muscle undergoing hypertrophy of old mice

indicated that rDNA transcription by RNA polymerase I was impaired. These results indicate

that the hypothesis was incorrect, impaired ribosome biogenesis was a primary factor

underlying the blunted hypertrophic response observed in skeletal muscle of old mice rather

than dramatic differences in the expression of protein-encoding genes. Therefore improved

ribosome biogenesis may result in an increased hypertrophic response observed in older



GHrow Matrix

So what is in OR1GIN that will increase ghrelin secretion and ribosome biogenesis? It utilizes

four effective ingredients supported by clinical data in one potent matrix to induce significant

muscle anabolism. The GHrow matrix is comprised of 750mg of Hesperidin Methyl Chalcone,

600mg of Gentian Root extract, 300mg of Robuvit® (Quercus Robur) extract and 300mg of

Actractylodes Chinesis that work in tandem to help you grow! These are likely not compounds

you would typically associate with a bodybuilding supplement and that is because OR1GIN is

atypical. There is no other natural product that is in the same realm as OR1GIN. It is an

exceptional formula that will provide exceptional results. As always, Olympus Labs builds our

formulations on thorough research and sound science which is reflected in the complete dosing

of each ingredient.. In fact, OR1GIN contains a very high dose of Robuvit® and Actractylodes

compared to dosages seen in the studies. So you can rest assured OR1GIN will maximize

muscle anabolism in order to build your ultimate physique.


Hesperidin is a flavanone glycoside or a sugar molecule consisting of the flavone hesperitin

bound to the disaccharide rutinose. It is naturally occurring in citrus fruits including oranges,

tangerines and grapefruits. Hesperidin has been shown to influence several biological functions,

including inhibiting tumor development and the proliferation of human cancer cells, as well as

the destruction of cancer cells. It also has antibacterial, antiviral, and antifungal properties. In

vivo studies have shown that hesperidin may also play a role in ghrelin secretion from the

stomach through antagonism of the serotonin receptors.

A study with mouse muscle cells was performed to assess the in vivo and in vitro effect of

hesperidin on myogenic differentiation (muscle tissue formation). The cells were analyzed in

the presence and absence of hesperidin for the in vitro portion of the study using several lab

testing methods, including reporter gene assays, immunoblotting, RT-PCR and DNA pull-down

assays. In vivo, the effects of hesperidin were assessed using the freeze injury-induced

muscle regeneration model in mice and daily injections of hesperidin for 6 days. Hesperidin

promoted myogenic differentiation, in a dose-dependent manner, by increasing myogenin gene

expression. Myogenin is a gene transcriptor in mice that plays a critical role in the development

of functional skeletal muscle. Hesperidin increased myogenin and muscle creatine kinase gene

expression during myogenic differentiation from C3H10T1/2 mesenchymal stem cells in a

MyoD-dependent manner and accelerated in vivo muscle regeneration induced by muscle

injury. These results indicate hesperedin can play a beneficial role in promoting muscle

regeneration, following injury.

Gentian root

Gentian root is a a herbal bitter that is derived from the perennial, Gentiana lutea L. It has

traditionally been used in the treatment of digestive disorders and is an ingredient of many

proprietary medicines. It contains secoiridoid glucosides which are some of the most bitter

compounds known and is used as a scientific basis for measuring bitterness. Gentiana lutea is

known to have several biological effects, such as anti-oxidant, anti-tumor and hepatoprotective

properties. Recent clinical research into Gentian root and other bitter compounds found that

observed improvements in digestion and appetite may at least be partly ascribed to the bitter

tonic effect. The increase in appetite that Gentian root provides can be attributed to its ability to

stimulate ghrelin secretion. If you want grow you will need to get those macros in and the

significant improvement in digestion that Gentiana lutea provides will make larger meals more

tolerable. At the substantial dosage included in OR1GIN it will be extremely effective in that



Robuvit® is a patented natural extract from French oak wood (Quercus robur) that is rich in

roburins and other flavonoids. It is typically used to improve liver dysfunction and chronic

fatigue. However, more pertinent to bodybuilding is its ability to reduce muscle soreness,

accelerate recovery and to induce changes in the function of the cellular protein factories called

ribosomes. Defective ribosomal function has been shown to be associated with several

diseases such as chronic fatigue syndrome (CFS). In addition, Robuvit® has passed extensive

safety tests and GLP (Good Laboratory Practice) studies,and is considered safe for human

consumption based on the fact no toxic effects have been observed or reported in clinical trials.

A clinical study confirmed human absorption of roburins from a French oak wood (Quercus

robur) water extract (Robuvit) by measuring the increase of total phenols (from 0.63 ± 0.06 to

1.26 ± 0.18 μg GAE equiv/mL plasma) and the appearance of three different roburin metabolites

(glucoronidate, urolithins and ellagic acid), in plasma, after 5 days of supplementation. Robuvit

supplementation also induced the increase of plasma antioxidant capacity from 1.8 ± 0.05 to 1.9

± 0.01 nmol Trolox equiv/mL plasma. The study concluded that Robuvit metabolites affect

ribosome, cell cycle, and spliceosome pathways.

A clinical study was performed to evaluate the effects of supplementation with Robuvit®

(Quercus robur wood extract, or &quot;QR&quot;) on performance and endurance in amateur athletes

training for a triathlon for a period of 2 weeks. All subjects, half which supplemented with

Robuvit® and 27 did not, completed 3 events; (swimming, biking and running). Each group

improved in training in each of the 3 events, however the improvement was greater with

Robuvit® (P<0.05) for the swim and biking (P<0.05); the running time decreased by 12.32% in

subjects using Robuvit® (3.6% in controls; P<0.05). The improvement the total triathlon time

was -10.56% with Robuvit® in comparison to -3.41% in controls. Post-run muscular pain,

cramps, localized pain, straining and the recovery time, were all considered better with QR

(P<0.05) based on plasma free radical (PFR) values 1 hour after the final run. After the final

test run triathlon athletes using QR had a lower increase of UBR and LDH (indicator of

hemolysis). These two tests were significantly increased in controls (P<0.05) but not in the

Robuvit® group. The observed improvements in triathlon athletes who supplemented are

significant since this group of athletes is among the best trained in the world, therefore it is

difficult to improve even further without severe training. In conclusion, Robuvit®

supplementation improved training, results and decreased hemolysis or the elimination of red

blood cells.. In addition, no side effects or tolerance problems were reported. .

Another clinical study investigated the effect of supplementation with Robuvit® (French Quercus

robur extract) capsules in subjects with Chronic Fatigue Syndrome (CFS) associated with

increased oxidative stress. The supplementation group consisted of 38 CFS subjects who

received 300 mg/day of Robuvit® and a control group of 42 comparable subjects who were

evaluated for 6 months following an initial 4 week washout period. Symptoms improved in both

groups with a significantly more important improvement in the supplement group (P<;0.05). The

single items in the Multidimensional Assessment of Fatigue (MAF) questionnaire were

statistically better improved (P<;0.05) in the supplement group. A parallel improvement in

oxidative stress was observed in the supplemented subjects. In the follow up, at 6 months no

organic disease was discovered or disease markers found. The study concluded that

supplementation with Robuvit® improves CFS in otherwise healthy subjects with no presence of

clinical disease or risk conditions.


Atractylodin is a derivative of the Atractylodes herb, a member of the Asteraceae family. There

are three different species: Atractylis lancea (Thunb.). DC., Atractylodes japonica Koidz.ez

Kitam and Atractylodes chinesis (DC.) koidz. It has been traditionally used as treatment for

several conditions including diarrhea, atrophy and flaccidity, arthralgia (joint pain) due to wind

and dampness and loss of appetite. Similar to Gentian root, the effect on appetite that

Atractylodin causes is indicative of ghrelin secretion. As detailed in the study below,

Atractylodin has been shown to be effective with hesperidin induces ghrelin receptor signaling.

Active components of rikkunshito, hesperidin and atractylodin, were given to tumor-bearing rats

to determine their efficacy as a treatment for cancer anorexia–cachexiaé It is a syndrome that

results in decreased food intake, weight loss, muscle tissue wasting and psychological distress,

and this syndrome is a major source of increased morbidity and mortality in cancer patients.

Corticotropin-releasing factor (CRF) decreased the plasma level of acyl ghrelin, and its receptor

antagonist, α-helical CRF, increased food intake of these rats. The serotonin 2c receptor (5-

HT2cR) antagonist SB242084 decreased hypothalamic CRF level and improved anorexia,

gastrointestinal (GI) dysmotility and body weight loss. The ghrelin receptor antagonist (D-Lys3)-

GHRP-6 worsened anorexia and hastened death in tumor-bearing rats. Ghrelin attenuated

anorexia–cachexia in the short term, but failed to prolong survival, as did SB242084

administration. In addition, the herbal medicine rikkunshito improved anorexia, GI dysmotility,

muscle wasting, and anxiety-related behavior and prolonged survival in animals and patients

with cancer. The appetite-stimulating effect of rikkunshito was blocked by (D-Lys3)- GHRP-6

Active components of rikkunshito, hesperidin and atractylodin potentiated ghrelin secretion and

receptor signaling, respectively, and atractylodin prolonged survival in tumor-bearing rats. Our

study demonstrates that the integrated mechanism underlying cancer anorexia–cachexia

involves lowered ghrelin signaling due to excessive hypothalamic interactions of 5-HT with CRF

through the 5-HT2cR. Potentiation of ghrelin receptor signaling may be an attractive treatment

for anorexia, muscle wasting and prolong survival in patients with cancer anorexia–cachexia.


Olympus Labs went to the OR1GIN to create fundamental anabolic staple for DemiGods. The

quest for the ultimate natural anabolic to facilitate your transformation from a mere mortal into a

DemiGod is complete. The King of Natural Anabolics has been crowned with inception of


With the reputation Olympus Labs has established for Innovation, Value and Results, you can

have complete confidence that OR1GIN will deliver a significant boost in muscle anabolism. By

stimulating ghrelin secretion and ribosome biogenesis, OR1GIN will increase appetite, energy

metabolism and muscle hypertrophy. There are no other natural supplements available that

can rival the anabolic potential of OR1GIN.

Whether you want to pack on muscle without the use of prohormones, to optimize a PH cycle or

maintain gains in PCT, OR1GIN has you covered. You had to ENDUR3 long enough without a

natural product with the impressive potential of OR1GIN. The wait is now over and It is time to

IGNIT3 your anabolic furnace and TR1IUMPH over mediocrity. You must begin at the OR1GIN

to build the ultimate, natural, physique and join the ranks of the DemiGods!



Directions: Take 3 capsules daily spread throughout the day.





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2. Kaczanowska et al. Microbiol Mol Biol Rev. 2007 Sep; 71(3): 477–494. doi:

10.1128/MMBR.00013-07. Ribosome Biogenesis and the Translation Process in

Escherichia coli

3. Thomson E et al. J Cell Sci. 2013 Nov 1;126(Pt 21):4815-21. doi: 10.1242/jcs.111948.

Eukaryotic ribosome biogenesis at a glance.

4. Stec MJ et al. Am J Physiol Endocrinol Metab. 2016 Feb 9:ajpendo.00486.2015. doi:

10.1152/ajpendo.00486.2015. [Epub ahead of print]. Ribosome biogenesis may

augment resistance training-induced myofiber hypertrophy and is required for myotube

growth in vitro.

5. Nakada S et al. PLoS One. 2016 Jan 29;11(1):e0147284. doi:

10.1371/journal.pone.0147284. eCollection 2016. Correlation between Ribosome

Biogenesis and the Magnitude of Hypertrophy in Overloaded Skeletal Muscle.

6. Kirby TJ et al. J Appl Physiol (1985). 2015 Aug 15;119(4):321-7. doi:

10.1152/japplphysiol.00296.2015. Epub 2015 Jun 5. Blunted hypertrophic response in

aged skeletal muscle is associated with decreased ribosome biogenesis.

7. Suzuki H et al. Recent Pat Food Nutr Agric. 2014;6(1):60-3. Hesperidin potentiates

ghrelin signaling.

8. Hana J et al. Br J Pharmacol. 2011 Jun; 163(3): 598–608. doi: 10.1111/j.1476-

5381.2011.01243.x. Hesperedin promotes MyoD-induced myogenic differentiation in

vitro and in vivo.

9. http://www.pfaf.org/user/Plant.aspx?LatinName=Gentiana+lutea

10. Olivier DK et al. J Ethnopharmacol. 2013 Jun 3;147(3):676-9. doi:

10.1016/j.jep.2013.03.059. Epub 2013 Mar 30. Bitterness values for traditional tonic

plants of southern Africa.

11. Kusar A et al. Human &amp; Experimental Toxicology (2006) 25: 599-604. Free radical

scavenging activities of yellow gentian (Gentiana lutea L.) measured by electron spin


12. McMullen MK et al. J Ethnopharmacol. 2014 Jul 3;154(3):719-27. doi:

10.1016/j.jep.2014.04.041. Epub 2014 May 5. Bitter tastants alter gastric-phase

postprandial haemodynamics.

13. http://www.robuvit.com/faq/

14. Natella F et al. J Agric Food Chem. 2014 Jan 15;62(2):443-53. doi: 10.1021/jf403493a.

Epub 2014 Jan 6. Absorption, metabolism, and effects at transcriptome level of a

standardized French oak wood extract, Robuvit, in healthy volunteers: pilot study

15. Vinciguerra MG et al. Minerva Cardioangiol. 2015 Oct;63(5):403-9. Robuvit® and

endurance in triathlon: improvements in training performance, recovery and oxidative


16. Belcaro G et al. J Neurosurg Sci. 2015 Jun;59(2):105-17. Epub 2014 Nov 14. Robuvit®

(Quercus robur extract) supplementation in subjects with chronic fatigue syndrome and

increased oxidative stress. A pilot registry study.

17. http://www.chineseherbshealing.com/atractylodes-cang- zhu/

18. N Fujitsuka et al. Transl Psychiatry. 2011 Jul; 1(7): e23. Published online 2011 Jul 26.

doi: 10.1038/tp.2011.25. Potentiation of ghrelin signaling attenuates cancer

anorexia–cachexia and prolongs survival

Disclaimer: While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists. Actual product packaging and materials may contain more and/or different information than that shown on our Web site. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. For additional information about a product, please contact the manufacturer. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Olympus Labs assumes no liability for inaccuracies or misstatements about products.

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